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目的 探讨间质性肺病 (ILD)支气管肺泡灌洗液 (BALF)Ⅲ型前胶原 (PⅢP)测定的临床意义。方法 应用放射免疫分析法 ,检测 3 1例ILD病例和 9例正常对照者的BALF中PⅢP含量 ,结合病程、病期及BALF中细胞成分的变化进行综合分析。结果 ( 1)ILD组BALF中PⅢP含量明显高于正常对照组 (P <0 .0 5 ) ;( 2 )BALF中PⅢP含量与ILD病程或病期有关 ,并与特发性肺纤维化BALF中性粒细胞百分比呈密切相关 (P <0 .0 1)。结论 BALF中PⅢP含量的测定 ,对辅助诊断ILD、纤维化程度的判断及活动性评价等均有重要临床意义。
Objective To investigate the clinical significance of the determination of type Ⅲ procollagen (P Ⅲ P) in bronchoalveolar lavage fluid (BALF) of patients with interstitial lung disease (ILD). Methods Radioimmunoassay was used to detect the content of PⅢP in BALF in 31 cases of ILD and 9 cases of normal controls, and to analyze the changes of disease course, disease period and the changes of cell components in BALF. Results (1) The content of PⅢP in BALF in ILD group was significantly higher than that in normal control group (P <0.05). (2) The content of PⅢP in BALF correlated with the duration or stage of ILD and was positively correlated with the level of PⅢP in idiopathic pulmonary fibrosis The percentage of granulocytes was closely related (P <0.01). Conclusions The determination of PⅢP content in BALF has important clinical significance for the diagnosis of ILD, the judgment of degree of fibrosis and the activity evaluation.