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本文随访20例Ⅱ型糖尿病,分析血糖,血清胰岛素和体重的动态变化,试探讨其发病机理。按对治疗的反应不同分为3组加以比较。结果表明Ⅱ型糖尿病胰岛素作用不足的原因既有胰岛素分泌不足,治疗后可有某种程度的逆转,也有外围胰岛素抵抗性增强。后一因素在肥胖型轻症者可能与胰岛素受体数目减少有关;在控制不良,高血糖及低胰岛素血症者可能与受体后过程有关,均为可逆性改变。
In this paper, 20 cases of type 2 diabetes were followed up to analyze the dynamic changes of blood glucose, serum insulin and body weight, to explore its pathogenesis. According to the different treatment response divided into 3 groups to be compared. The results showed that insulin deficiency in type 2 diabetes due to inadequate insulin secretion, after treatment may have some degree of reversal, but also peripheral insulin resistance increased. The latter factor in obese mild cases may be related to the decrease of insulin receptor number; in poor control, hyperglycemia and hypoproteinemia may be related to post-receptor process, are reversible changes.