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对８例健康志愿者，１１例慢性肾功能衰竭患者（Ｃｃｒ＜１０ｍｌ／ｍｉｎ）静脉恒速滴注乳酸环丙沙星２００ｍｇ（３０ｍｉｎ）注射液后的临床药物动力学进行了研究，用高效液相色谱法对血清中环丙沙星进行测定，主要药动学参数分别是滴注完时浓度Ｃｏ健康人组为２．２６ｍｇ／Ｌ，未透析组为２．５２ｍｇ／Ｌ，血透组为２．３７ｍｇ／Ｌ，腹透组为２．３５ｍｇ／Ｌ。清除相半衰期健康人为２．７±０．８ｈ，未透析组为１５±４ｈ，血透组为５．０±１．９ｈ，腹透组为６．３±２．７ｈ。表明慢性肾功能衰竭患者的环丙沙星药物动力学过程较健康者有明显的改变，根据以上数据提出慢性肾功能衰竭时的一些给药方案
Clinical pharmacokinetics of 8 healthy volunteers and 11 patients with chronic renal failure (Ccr <10ml / min) intravenous infusion of 200mg (30min) ciprofloxacin intravenous infusion were studied. The determination of ciprofloxacin in serum by phase chromatography was carried out. The main pharmacokinetic parameters were 2.26 mg / L in Co-treated group, 2.52 mg / L in non-dialysis group and 2 in hemodialysis group .37mg / L, peritoneal group was 2.35mg / L. Clear phase half-life of healthy people 2.7 ± 0.8h, not dialysis group 15 ± 4h, hemodialysis group 5.0 ± 1.9h, peritoneal dialysis group was 6.3 ± 2.7h. Indicating that chronic ciprofloxacin patients with ciprofloxacin pharmacokinetic process than in those with significant changes, based on the above data put forward some of the chronic renal failure when the dosing regimen