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微卫星的异常改变(MSI和LOH)被认为是肿瘤发生的另一机制,MSI和LOH是影响肿瘤临床病理特性的重要因素。微卫星的检测技术简便易行,它可以用于判断预后,检测癌前病变组织。全文就近几年肿瘤微卫星异常改变的有关文献,阐述了MSI和LOH在肿瘤发生发展过程中的作用,及其在癌前病变监测和肿瘤防治中的临床意义。
Aberrations of microsatellites (MSI and LOH) are considered as another mechanism of tumorigenesis. MSI and LOH are important factors that influence the clinicopathological features of tumors. Microsatellite detection technology is simple and easy, it can be used to determine the prognosis, detection of precancerous lesions. Full text The recent years, microsatellite anomalies of the relevant literature on the MSI and LOH elaborated the role of tumor development and progression, and its precancerous lesions in the prevention and treatment of cancer clinical significance.