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目的 探讨大鼠运动病敏感性与血浆皮质醇 (CORT)和促肾上腺皮质激素 (ACTH)含量的关系,进一步阐明体液因素在运动病发病中的作用。方法 采用大鼠条件性厌食症 (CTA)作为运动病模型和分组。84只雌性大鼠, 12只用于正常对照; 36只用于旋转刺激后大鼠血浆激素水平的测定(采用放射免疫分析法);另 36只用于前庭功能锻炼后大鼠血浆激素水平的测定。结果 大鼠运动病后血浆CORT和ACTH含量升高(P<0. 01),低敏感组[分别为(34. 51±6. 13)ng/ml和 (22. 42±3. 66)pg/ml]高于高敏感组[ (25. 74±4. 88)ng/ml和 (15. 88±3. 52)pg/ml] (P<0 01);功能锻炼后产生适应的高敏感组运动病大鼠血浆CORT、ACTH含量[ (29. 60±5. 99)ng/ml, (19. 83±6. 87)pg/ml]与低敏感组[ (34. 78±6. 37)ng/ml, (25. 37±6. 36)pg/ml]差异无统计学意义。结论 运动病与应激有关,运动病敏感性与血浆CORT、ACTH含量有关。
Objective To investigate the relationship between motion sickness and plasma cortisol (CORT) and adrenocorticotropic hormone (ACTH) content in rats and further elucidate the role of humoral factors in the pathogenesis of motion sickness. Methods Rats with conditioned anorexia (CTA) were used as model and grouping of motion sickness. 84 female rats, 12 for the normal control; 36 for the rat plasma hormone levels after rotation stimulation (using radioimmunoassay); and the other 36 for the vestibular function of rat plasma hormone levels Determination. Results The plasma levels of CORT and ACTH were significantly increased after exercise (P <0.01) in low-sensitivity group [(34.5 ± 6.13) ng / ml and (22.42 ± 3.66) pg / ml] was higher than that in the hypersensitive group [(25.74 ± 4.88) ng / ml and (15.88 ± 3.52) pg / ml], respectively The levels of plasma CORT and ACTH in the group of motion sickness rats were significantly lower than those in the low sensitive group [(34.8 ± 5.99) ng / ml, (19.83 ± 6.77) pg / ml] ) ng / ml, (25.37 ± 6.36) pg / ml] had no statistical significance. Conclusion The motion sickness is related to stress. The motion sickness sensitivity is related to the content of plasma CORT and ACTH.