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目的研究肝癌组织端粒酶活性与肝癌病理类型之间的关系。方法原发性肝癌分为4种病理类型:块状型、结节型、小癌型和弥散型。端粒酶活性用端粒酶PCR-ELASA法检测。结果 89.4%(42/47)的肝癌标本可测到端粒酶活性,尽管不同类型肝癌的端粒酶阳性率不同,但差异无显著性(P>0.05)。结论大多数肝癌标本呈端粒酶阳性,但端粒酶阳性率与肝癌病理类型间无关联。
Objective To study the relationship between the telomerase activity of liver cancer and the pathological type of liver cancer. Methods Primary liver cancer is divided into four pathological types: massive, nodular, small carcinoma and diffuse type. Telomerase activity was detected by telomerase PCR-ELASA. Results Telomerase activity was detected in 89.4% (42/47) of the HCC specimens. Although the telomerase positive rate was different in different types of HCC, the difference was not significant (P> 0.05). Conclusion Most of the specimens of HCC are telomerase positive, but the positive rate of telomerase is not related to the pathological types of HCC.