作者对门静脉高压症患者胃粘膜损害的发生机理,进行实验和临床研究。结果报告如下。对象和方法用Wistar系雄鼠,通过部分结扎法制成门静脉高压症模型。然后通过内镜检查法、病理组织像,门静脉压力、胃粘膜血流量和粘膜实体的显微镜下变化等,进行动态观察。临床病例系选自庆应癌症研究中心过去3年内的食管静脉曲张患者。在部分病例中,通过激光多普勒 The author of the pathogenesis of gastric mucosal damage in patients with portal hypertension, experimental and clinical studies. The results are reported below. Subjects and methods Male Wistar rats were used to model portal hypertension by partial ligation. Then dynamic observation was performed by endoscopy, histopathology, portal pressure, gastric mucosal blood flow, and microscopic changes of mucosal entities. Clinical cases were from patients with esophageal varices in the past three years at the Keegan Cancer Research Center. In some cases, laser Doppler