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目的 研究转化生长因子 β(TGF - β)及其受体在胃癌中的表达 ,探讨其在胃癌发病中的作用机制及临床意义。方法 应用免疫组织化学SABC方法进行研究。结果 TGF - β表达主要分布于肿瘤细胞浆中 ,其在胃癌中的表达率 71 43%明显高于正常组织的 2 3 2 1% ,P <0 .0 5。TGF - βⅠ型受体表达主要分布于细胞膜和细胞浆中 ,其在胃癌和正常组织中的表达无明显差异 ,P >0 .0 5。TGF - βⅡ型受体表达亦位于细胞膜和细胞浆中 ,其在胃癌中的阳性表达率 44 6 4%明显低于正常组织的 96 43% ,P <0 .0 1。结论 TGF - β表达与胃癌发生、发展有着密切关系 ,其受体表达的缺失可能是肿瘤细胞逃逸TGF - β负调控的机制之一
Objective To investigate the expression of transforming growth factor β (TGF - β) and its receptor in gastric cancer and its possible mechanism and its clinical significance in the pathogenesis of gastric cancer. Methods Immunohistochemical SABC method was used to study. Results The expression of TGF - β was mainly distributed in tumor cell cytoplasm. The expression of TGF - β in gastric cancer was significantly higher than that in normal tissue (71 43%, P <0. 05). The expression of TGF - β Ⅰ receptor mainly distributed in the cell membrane and cytoplasm, and there was no significant difference in the expression of TGF - β Ⅰ receptor in gastric cancer and normal tissues (P> 0.05). The expression of TGF - β Ⅱ receptor was also located in the cell membrane and cytoplasm. The positive rate of TGF - β Ⅱ receptor in gastric carcinoma was 44 6 4%, which was significantly lower than that of normal tissue 96 43%, P <0.01. Conclusion The expression of TGF - β is closely related to the occurrence and development of gastric cancer. The loss of its receptor expression may be one of the mechanisms by which tumor cells escape the negative regulation of TGF - β