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阿齐红霉素的结构和抗菌谱与红霉素相似,口服后在血清中的浓度低于红霉素,而在组织中的浓度高于红霉素,半衰期比红霉素长。已发现阿齐红霉素单剂口服治疗衣原体性尿道炎或宫颈炎与红霉素及其他常用于7天疗程的药物疗效相当。该研究旨在评价阿齐红霉素1.0g单剂口服对衣原体性宫颈炎的疗效和耐受性及其在宫颈粘液和血浆中的动力学特点。
The structure and antibacterial spectrum of azithromycin is similar to that of erythromycin, and its concentration in serum after oral administration is lower than that of erythromycin, while its concentration in tissues is higher than that of erythromycin and the half-life is longer than that of erythromycin. A single dose of azithromycin has been found to be effective in the treatment of chlamydial urethritis or cervicitis with erythromycin and other medications commonly used in the 7-day course. The aim of this study was to evaluate the efficacy and tolerability of azithromycin 1.0g monotherapy for chlamydial cervicitis and its kinetic characteristics in cervical mucus and plasma.