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目的建立合理的乙型肝炎病毒(HBV)医院感染监控方法。方法在阐明接种血量、感染阈值和病毒标志相互关系的基础上,将HBV医院感染分类,选择传染源替代指标,确定医院感染监控方法。结果乙型肝炎表面抗原(HBsAg)阳性和阴性、乙型肝炎e抗原(HBeAg)阳性和阴性者的传染性强度分别为73.7%和9.0%,100.0%和67.2%;传染性范围分别在0～109、0～104、102～109和0～106ID/ml;血量与HBV感染阈值呈负相关、与传染性强度呈正相关,<10-7ml时只有HBeAg阳性者具有传染性,<10-4ml时HBeAg阳性和阴性HBsAg携带者均具有传染性,>10-4ml时所有HBV携带者均具有传染性。结论将HBV医院感染分为经大量、小量和微量血液传播3种类型,分别选择HBV DNA、HBsAg和HBeAg作为传染源替代指标,使用相应的监控方法。
Objective To establish a reasonable monitoring method of Hepatitis B virus (HBV) hospital infection. Methods Based on the elucidation of the relationship between inoculation blood volume, infection threshold and virus sign, HBV infection in hospital was classified and indicators of infection were selected to determine the surveillance method of nosocomial infection. Results The infectious intensities of HBsAg positive and negative, HBeAg positive and negative were 73.7%, 9.0%, 100.0% and 67.2%, respectively. The infectious range was 0 ~ 109,0-104,102-109 and 0-106ID / ml. The blood volume was negatively correlated with the threshold of HBV infection and positively correlated with the infectious intensity. Only those with HBeAg positive were less than 10-4ml Both HBeAg-positive and HBsAg-carriers are contagious, and all HBV carriers> 10-4 ml are contagious. Conclusions HBV hospital infection is divided into three types: large quantity, small quantity and trace blood. HBV DNA, HBsAg and HBeAg are selected as the source of infection instead of indicators, and the corresponding monitoring methods are used.