School is an ideal setting in which to reach and impact chil-dren and adolescents in order to improve their health and well-ness. A large number of scholarly articles have been published on the subject of school-based physical activity (PA) and well-ness promotion. However, given the diversity of schools world-wide, intervention programs, curricula, and strategies are notone size fits all and may not be universally applicable. The inconsistent application of theoretical frameworks and various measurement methods further muddles the evidence. One prob-lem with many school-based PA and wellness interventions is their prospect for generalization and sustainability. In recent years, many researchers have ted attention to devising inter-ventions, including school-based interventions targeting chil-dren and adolescents, to reduce health-compromising sedentary behavior, as well as to promote health-enhancing PA. Addi-tional evidence—and stronger evidence than currently avail-able—is needed to shed light on how these interventions can and should be scaled up, implemented, disseminated, and adopted more broadly in schools and populations.