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以１２５Ⅰ－ＬＤＬ为配体对食管癌、胃癌及其相应的正常组织进行了ＬＤＬ受体水平的测定，同时分析了各组织中蛋白质、ＤＮＡ的含量，以探讨食管癌和胃癌发生与ＬＤＬ代谢之间的关系。结果显示，癌组织和正常组织的ＬＤＬ受体亲和性差异无显著性，但癌变组织的蛋白质、ＤＮＡ和ＬＤＬ受体水平均明显高于相应正常组织。癌细胞需要大量的胆固醇满足其有丝分裂，细胞通过受体升高机制使ＬＤＬＲ增多，以增加对ＬＤＬ的摄取和利用。
Using 125I-LDL as a ligand, LDL receptor levels were measured in esophageal cancer, gastric cancer, and their normal tissues. The contents of protein and DNA in tissues were analyzed to investigate the occurrence of esophageal and gastric cancers and LDL metabolism. Relationship between. The results showed that there was no significant difference in LDL receptor affinity between cancerous tissues and normal tissues, but the levels of protein, DNA, and LDL receptors in cancerous tissues were significantly higher than those in normal tissues. Cancer cells require a large amount of cholesterol to meet their mitosis. The cells increase the LDLR through the receptor elevation mechanism to increase the uptake and utilization of LDL.