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目的:探讨5例罕见的双侧嗅裂区呼吸道上皮腺瘤样错构瘤(REAH)的临床病理特点。方法:结合文献复习,报告5例经病理证实的REAH患者。结果:4例以鼻塞,流涕为首要主诉,伴或不伴嗅觉减退、头痛,1例以头面部不适为首要主诉,偶有流脓涕及涕中带血。5例鼻腔中鼻道可见息肉样新生物。所有患者均行鼻窦内镜手术清除病灶,REAH病灶均位于双侧嗅裂区,4例外观呈息肉样改变,1例炎性水肿明显,均较息肉质韧,并且基底弥漫,内衬表面上皮源性纤毛呼吸上皮的腺体异常增生为REAH病理学特征,腺体围成圆形或椭圆形,大小不一,被一些间质组织所分隔。结论:REAH如果不彻底切除,有术后继续生长的可能性,故鼻内镜手术时,完全彻底清除病灶是手术成功的关键。尽管鼻腔鼻窦区域的REAH非常少见,但应与内翻乳头状瘤以及腺癌相鉴别。
Objective: To investigate the clinicopathological features of 5 cases of rare respiratory tract epithelial adenomatous hamartoma (REAH). Methods: According to the literature review, 5 cases of pathologically confirmed REAH were reported. Results: In 4 cases, nasal obstruction and runny nose were the main complaints, with or without hypodermic sensation and headache. One patient complained of head and face discomfort as the chief complaint. 5 cases of nasal nasal polyps can be seen like new creatures. All patients underwent endoscopic sinus surgery to clear the lesion, REAH lesions were located in bilateral olfactory fissure area, 4 cases of polypoid appearance of the change in appearance, 1 case of inflammatory edema were more tough than polypoid, and diffuse basal, lining the surface epithelium Source cilia respiratory epithelial abnormalities of the glands for the pathological features of REAH, the gland surrounded by a round or oval, different sizes, separated by some interstitial tissue. Conclusion: If REAH is not completely resected, there is a possibility of continued growth after surgery. Therefore, complete and complete removal of the lesion during endoscopic sinus surgery is the key to successful operation. Although rare in the nasal sinus area, REAH should be differentiated from inverted papilloma and adenocarcinoma.