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目的:探讨参麦注射液对化疗后女性乳腺癌患者的心脏保护作用。方法:897例新疆乳腺癌患者随机分为对照组(436例)和治疗组(461例),对照组给予环磷酰胺、阿霉素、5-氟尿嘧啶化疗(CAF方案),治疗组在对照组基础上加用参麦注射液,总疗程6个月。观察2组患者化疗前后心电图、动态心电图及心肌酶谱的变化。结果:治疗组较对照组能降低乳酸脱氢酶、肌酸激酶、肌钙蛋白(P<0.05)及心电图、动态心电图的阳性发生率(P<0.05)。结论:参麦注射液有显著的预防化疗所致的心肌损伤作用。
Objective: To investigate the protective effect of Shenmai injection on the breast cancer patients after chemotherapy. Methods: 897 cases of breast cancer in Xinjiang were randomly divided into control group (436 cases) and treatment group (461 cases). The control group was given cyclophosphamide, doxorubicin and 5-fluorouracil chemotherapy (CAF regimen) Based on the use of Shenmai injection, the total course of 6 months. The changes of ECG, dynamic electrocardiogram and myocardial enzymes in two groups before and after chemotherapy were observed. Results: Compared with the control group, the treatment group could reduce the positive rate of lactate dehydrogenase, creatine kinase, troponin (P <0.05) and electrocardiogram and electrocardiogram (P <0.05). Conclusion: Shenmai injection has a significant preventive effect on myocardial injury caused by chemotherapy.