目的　探索促进许旺细胞增殖的方法。方法　将原代大鼠许旺细胞进行体外培养 ,并在培养基中加入不同浓度的胰岛素样生长因子 1(IGF -1)。通过绘制细胞生长曲线及3 H -TdR渗入等方法 ,观察IGF -1对许旺细胞的作用。结果　IGF -1能使培养的许旺细胞增殖加快 ,提前进入平台期。许旺细胞的增殖与IGF -1的浓度在一定范围内呈现量效关系 ,同时IGF -1的作用并不导致许旺细胞的肥大。结论　IGF -1对许旺细胞增殖具有明显的促进作用。 Objective To explore ways to promote the proliferation of Schwann cells. Methods The primary rat Schwann cells were cultured in vitro and different concentrations of insulin - like growth factor 1 (IGF - 1) were added into the culture medium. The effects of IGF-1 on Schwann cells were observed by drawing cell growth curve and 3 H-TdR infiltration. Results IGF-1 could accelerate the proliferation of Schwann cells and advance into plateau. Schwann cell proliferation and IGF-1 concentrations show a dose-response relationship within a certain range, while the role of IGF-1 does not lead to Schwann cell hypertrophy. Conclusion IGF-1 can significantly promote the proliferation of Schwann cells.