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大剂量盐酸异丙基肾上腺素(简称异丙肾)可致大鼠发生非特异性心肌坏死。探讨预防这种心肌坏死的有效措施,对预防坏死性心肌疾病有实用意义。近年来,辅酶Q_(10)对心肌的保护作用引人注目。岳中典男用辅酶Q_(10)预防异丙肾所致的大鼠心肌坏死,明显减轻了心肌坏死的程度,并认为保护心肌线粒体是辅酶Q_(10)预防心肌坏死的主要机理。探讨异丙肾致大鼠心肌坏死机理的研究表明,注射异丙肾后,大鼠血浆和心肌的cAMP含量明显增加,并由此引起心肌代谢紊乱和功能异常。提示血浆和心肌cAMP含量的变化可能与心肌坏死的发生有关。Martorana以注射二丁酰cAMP的方法使大鼠发生与异丙肾所致者相同的心肌坏死,进一步提示cAMP在异丙肾致心肌
High-dose isopropyl epinephrine hydrochloride (referred to as isoproterenol) can cause non-specific myocardial necrosis in rats. To explore effective measures to prevent this myocardial necrosis, to prevent necrotic myocardial disease has practical significance. In recent years, the protective effect of coenzyme Q_ (10) on myocardium attracts attention. Yuezhongdian male with the coenzyme Q_ (10) to prevent myocardial ischemia induced by isoproterenol, significantly reduce the degree of myocardial necrosis, and that the protection of myocardial mitochondria is coenzyme Q_ (10) the main mechanism of preventing myocardial necrosis. To investigate the mechanism of isoproterenol-induced myocardial necrosis in rats showed that injection of isoproterenol, rat plasma and myocardial cAMP content increased significantly, and thus cause myocardial metabolic disorders and dysfunction. Tip plasma and myocardial cAMP content changes may be related to the occurrence of myocardial necrosis. Martorana injection of dibutyryl cAMP in rats with isoproterenol caused by the same myocardial necrosis, and further prompted cAMP in the isoproterenol induced myocardium