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作者对22个肾透析中心的814例透析患者和177名工作人员接种乙型肝炎疫苗。每剂40μg。共有444例患者和128名工作人员完成了3剂免疫程序,并在第3针后至少两周测定了抗体。15个临床实验室中有11个采用放射免疫法(RIA)测定,抗体比值单位大于2.1判为阳性;其他实验室采用ELISA检测,以血清吸收值大于平均阴性对照+0.05为阳性。 444例患者的平均年龄为56岁,其中男性251例。接种3针疫苗后,有208例(47%)患者出现抗体阳转。抗体阳转率与年龄相关,30岁以下为86%,70岁以上为32%。女性可能比男性更易产生抗体,阳转率分别为51%和
The authors vaccinated 814 dialysis patients and 177 staff in 22 renal dialysis centers. 40μg per dose. A total of 444 patients and 128 staff completed 3 immunization schedules and antibodies were measured at least 2 weeks after the 3 rd needle. Eleven of the 15 clinical laboratories were assayed by radioimmunoassay (RIA) and the antibody titer greater than 2.1 was judged positive; in other laboratories, ELISA was used and the serum absorption was greater than the mean negative control +0.05. The average age of 444 patients was 56 years, of which 251 were males. After vaccination with the 3-dose vaccine, 208 (47%) patients developed positive antibody. Antibody positive rate was age-related, with 86% under 30 years of age and 32% over 70 years of age. Women may develop antibodies more easily than men, with positive rates of 51% and