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为改进抗肿瘤活性、降低心脏毒性,我院曾合成了一系列柔红霉素和阿霉素的类似物。其中,7-O-(反式-4′-氨基环己烷甲酰)阿霉酮盐酸盐(合1028)在小鼠白血病L7712或P388抑瘤试验中给出了与阿霉素相当的生命延长率。
In order to improve antitumor activity and reduce cardiotoxicity, our hospital has synthesized a series of daunorubicin and doxorubicin analogues. Among them, 7-O- (trans-4’-aminocyclohexanecarboxamido) doxorubicin hydrochloride (combined 1028) gave doxorubicin equivalent in mouse leukemia L7712 or P388 antitumor assay Life extension rate.