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目的:在监测对婴幼儿不能进行常规剂量给药的情况时,采用每日1次剂量(OD)给予庆大霉素的方法是否合适。方法:采用开放、随机对照试验,受试婴儿为肯尼亚农村地区医院新近收治的、怀疑为严重脓毒症的患儿,庆大霉素治疗分为1日1次给药和常规的1日多次(MD)给药两组。结果:在297例随机分组的患儿中,最
OBJECTIVE: To determine if gentamicin is given in a single daily dose (OD) when monitoring the inability of infants and young children to be dosed regularly. METHODS: An open-label, randomized, controlled trial of infants who were newly admitted to rural hospitals in Kenya and who were suspected of having severe sepsis was divided into 1-day gentamicin treatment and 1-day routine (MD) administered two groups. Results: Of 297 children randomized to the highest