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目的探讨急性重症胆管炎(ACST)乳酸脱氢酶(LDH)、血小板(PLT)与凝血功能之间的关系。方法对急诊入院的42例ACST患者立刻采血,分别测定LDH、PLT、血浆纤维蛋白原(Fib)、血管性血友病因子(vWF)、纤维蛋白A肽(FPA)、血小板a颗粒膜蛋白-140(GMP-140)、抗凝血酶-Ⅲ(AT-Ⅲ)含量,并与正常对照组比较。结果与正常对照组比较,重症胆管炎患者LDH、vWF、GMP-140、FPA显著增高(P<0.05),PLT、AT-Ⅲ则显著降低(P<0.05),而Fib无显著差异(P>0.05)。结论重症胆管炎患者存在明显的组织损伤和凝血、抗凝血系统的功能紊乱,通过对ACST患者LDH、PLT及凝血功能的观察,可作为了解ACST病情严重程度和预后评估的客观指标。
Objective To investigate the relationship between acute severe cholangitis (ACST) lactate dehydrogenase (LDH), platelet (PLT) and coagulation function. Methods Forty - two ACST patients admitted to the emergency department were enrolled in this study. LDH, PLT, fibrinogen (Fib), vWF, fibrinogen A (FPA) and platelet membrane protein - 140 (GMP-140), antithrombin-Ⅲ (AT-Ⅲ) content, and compared with the normal control group. Results The levels of LDH, vWF, GMP-140 and FPA were significantly increased in patients with severe cholangitis (P <0.05), while those in PLT and AT-Ⅲ were significantly lower than those in normal controls (P < 0.05). Conclusions There are obvious tissue damage, coagulation and anticoagulant dysfunction in patients with severe cholangitis. The observation of LDH, PLT and coagulation function in patients with ACST can be used as an objective index to evaluate the severity and prognosis of ACST.