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肾细胞癌的转移是一个多环节、多步骤相互作用的复杂过程.近年来在遗传学、分子生物学、组织学和病理学等方面取得了显著进展,对提高肾细胞癌转移的早期预测,开展特异性分子靶向治疗和改善患者预后具有重要意义。本文对肾细胞癌转移相关的降低细胞外基质酶类、细胞黏附分子、促血管生长因子、免疫调节分子和转移相关基因等有关的分子标志物及其与肿瘤转移早期诊断及预后监测的关系进行了综述。
The metastasis of renal cell carcinoma is a complex process of multi-step and multi-step interaction, and in recent years, remarkable progress has been made in genetics, molecular biology, histology and pathology, etc. In order to improve the early prediction of renal cell carcinoma metastasis, To carry out specific molecular targeted therapy and improve the prognosis of patients is of great significance. In this paper, the molecular markers of extracellular matrix enzymes, cell adhesion molecules, pro-angiogenic growth factors, immune regulatory molecules and metastasis-related genes related to the metastasis of renal cell carcinoma and their relationship with the early diagnosis and prognosis monitoring of tumor metastasis A review