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目的研究帕金森病(PD)及异动症大鼠模型纹状体的自发性电活动变化。方法6-羟多巴(6-OHDA)立体定位注射制备偏侧PD大鼠模型,复方左旋多巴腹腔注射治疗4周诱发异动症(levodopa in-duced-dyskinesias LID)大鼠模型,采用微电极细胞外记录技术检测PD及LID大鼠模型纹状体的电生理活动。结果PD大鼠纹状体细胞的自发电活动较对照组明显增多,左旋多巴治疗后恢复正常。LID大鼠则自发性电活动再次增加,而重度LID大鼠又较轻度LID大鼠自发性电活动明显增强。结论纹状体多棘神经元的自发性电活动改变是PD及LID的重要发病机制之一。
Objective To study the changes of spontaneous electrical activity in the striatum of Parkinson’s disease (PD) and dyskinetic rats. Methods The hemiparkinsonian model of hemiparkinsonism was established by stereotactic injection of 6-hydroxydopamine (6-OHDA). The rat model of levodopa in-duced-dyskinesias (LID) Extracellular recording technique was used to detect the electrophysiological activity of striatum in PD and LID rat models. Results PD rat striatum cells spontaneous activity was significantly increased compared with the control group, levodopa treatment returned to normal. The spontaneous electrical activity of LID rats increased again, while the spontaneous electrical activity of severe LID rats and mild LID rats increased significantly. Conclusion The change of spontaneous electrical activity of striatum spike neurons is one of the important pathogenesis of PD and LID.