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目的探讨血清胎球蛋白A对妊娠期糖尿病孕妇胰岛素抵抗和糖脂代谢的意义。方法选择妊娠期糖尿病患者49例为观察组,选择同期正常血糖妊娠者50例为对照组,观察两组患者分娩前AHSG、FPG、HOMA-IRI、空腹胰岛素、餐后2h胰岛素、HbA1c和血脂等指标变化情况。结果观察组AHSG、FPG和HOMA-IRI水平均显著高于对照组(P<0.05);观察组空腹胰岛素、餐后2h胰岛素水平和HbA1c比值均显著高于对照组(P<0.05);观察组TC、TG和LDL-C水平均高于对照组(P<0.05),而HDL-C水平则显著低于对照组(P<0.05)。结论胎球蛋白A水平与妊娠期糖尿病胰岛素抵抗密切相关,同时影响患者血脂代谢。
Objective To investigate the significance of serum fetuin A on insulin resistance and glucose and lipid metabolism in pregnant women with gestational diabetes mellitus. Methods Forty-nine patients with gestational diabetes mellitus (DM) were selected as the observation group. 50 normal pregnant women with gestational blood glucose during the same period were selected as the control group. AHSG, FPG, HOMA-IRI, fasting insulin, postprandial insulin, HbA1c, Indicator changes. Results The levels of AHSG, FPG and HOMA-IRI in the observation group were significantly higher than those in the control group (P <0.05). The levels of fasting insulin, postprandial 2h insulin and HbA1c in the observation group were significantly higher than those in the control group (P <0.05) TC, TG and LDL-C levels were higher than the control group (P <0.05), while HDL-C levels were significantly lower than the control group (P <0.05). Conclusion The level of fetuin A is closely related to insulin resistance in gestational diabetes mellitus, and affects the blood lipid metabolism in patients.