论文部分内容阅读
目的探讨初诊的老年2型糖尿病患者应用甘精胰岛素的临床疗效。方法 94例老年2型糖尿病患者,随机分为观察组与对照组,各47例,对照组给予格列吡嗪治疗,观察组给予甘精胰岛素治疗,对比两组临床效果。结果治疗后,两组患者空腹血糖、餐后血糖、糖化血红蛋白均得到改善,但两组的改善情况差异无统计学意义(P>0.05);观察组患者发生低血糖次数明显低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者的空腹C肽及空腹2 h C肽均明显改善,且观察组患者改善程度优于对照组,差异具有统计学意义(P<0.05)。结论甘精胰岛素治疗初诊的老年2型糖尿病患者效果好,血糖控制理想,且低血糖发生率低,患者胰岛β细胞功能改善良好。
Objective To investigate the clinical efficacy of insulin glargine in newly diagnosed type 2 diabetic elderly patients. Methods Ninety-four elderly patients with type 2 diabetes mellitus were randomly divided into observation group (n = 47) and control group (n = 47). The control group was treated with glipizide. The observation group was given insulin glargine. The clinical effects were compared between the two groups. Results After treatment, the fasting blood glucose, postprandial blood glucose and HbA1c in both groups were improved, but there was no significant difference between the two groups (P> 0.05); the incidence of hypoglycemia in the observation group was significantly lower than that in the control group, (P <0.05). After treatment, the fasting C-peptide and fasting 2-h C peptide in both groups were significantly improved, and the improvement in the observation group was better than that in the control group, the difference was statistically significant (P < 0.05). Conclusion Glargine treatment of newly diagnosed type 2 diabetes in elderly patients with good effect, ideal blood glucose control, and low incidence of hypoglycemia, patients with pancreatic β-cell function improved well.