基因治疗作为一种新型的治疗手段,在心脏疾病的治疗中显示出广阔的前景。选用合适的载体将目的基因导入心肌细胞并使其高效表达,是心脏疾病基因治疗的关键一步。腺相关病毒具有高稳定性、低致病性、低免疫原性、可长期表达等优点,是目前最具发展前景的一类病毒载体。本文主要概述了腺相关病毒在心脏基因转导中的应用。 Gene therapy as a new type of treatment shows great promise in the treatment of heart diseases. It is a key step in the gene therapy of heart diseases to select suitable vectors and transfer the target gene into cardiomyocytes for high expression. Adeno-associated virus has the advantages of high stability, low pathogenicity, low immunogenicity and long-term expression. It is the most promising viral vector at present. This article summarizes the application of adeno-associated virus in cardiac gene transduction.