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目的研究ⅢA期非小细胞肺癌(NSCLC)患者手术前单疗程化疗前后肺功能的变化,评价其对术前肺功能的影响。方法从2002年8月至2003年2月,对72例ⅢA期NSCLC进行术前化疗1个疗程。其中鳞癌38例采用CAP方案,腺癌34例采用FAD方案治疗。化疗前及化疗结束后10 d检查第一秒用力呼出量(FEV1%)、一氧化碳弥散能力(DLCO%)、动脉血气分析(PaO2、PaCO2)做自身对照。结果手术前化疗前后FEV1%、DLCO%、PaO2、PaCO2分别为78.37%±1.05%、79.06%±0.92%;80.48%±0.13%、80.25%±0.12%;(83.59±0.66)mmHg、(83.90±0.68)mmHg;(39.18±0.43)mmHg、(39.09±0.38)mmHg。两组比较差异无统计学意义(P<0.05)。结论手术前单疗程化疗对CNSCLC患者肺功能无明显影响。
Objective To study the changes of lung function in patients with stage Ⅲ A non-small cell lung cancer (NSCLC) before and after single-course chemotherapy before operation and evaluate the effect on preoperative pulmonary function. Methods From August 2002 to February 2003, 72 patients with stage Ⅲ A NSCLC underwent a course of preoperative chemotherapy. 38 cases of squamous cell carcinoma using CAP program, adenocarcinoma of 34 cases treated with FAD program. Before treatment and 10 days after chemotherapy, the first second forced expiratory volume (FEV1%), carbon monoxide dispersion capacity (DLCO%), arterial blood gas analysis (PaO2, PaCO2) as their own control. Results Before operation, FEV1%, DLCO%, PaO2 and PaCO2 were 78.37% ± 1.05%, 79.06% ± 0.92%, 80.48% ± 0.13%, 80.25% ± 0.12%, 83.59 ± 0.66 mmHg, 83.90 ± 0.68) mmHg; (39.18 ± 0.43) mmHg, (39.09 ± 0.38) mmHg. There was no significant difference between the two groups (P <0.05). Conclusions Single-course chemotherapy before surgery has no significant effect on pulmonary function in patients with CNSCLC.