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卵巢癌患者接受烷化剂类药物化疗会增加急性白血病(尤其是髓系白血病)的危险。本文对99133例卵巢癌幸存者中的114例白血病进行了对照研究。每个病例均经严格筛选并设立相配的3个对照病例,以消除潜在因素的影响。本组74%的白血病发生于卵巢癌确诊后2～9年内,其中急性或非淋巴细胞白血病占总白血病数的89%。治疗方法不同其相对危险性亦不同。若以单纯外科治疗的相对危险性定为1,则单纯化疗的危险性为12,比放疗加化疗的10要高,但两者差别并不明显。单纯放疗相对危险性为1.6,仅略有增加。
Ovarian cancer patients receiving alkylating agent chemotherapy may increase the risk of acute leukemia, especially myeloid leukemia. In this paper, a control study of 114 leukemias among 99,133 ovarian cancer survivors was performed. Each case was rigorously screened and matched with 3 control cases to eliminate the influence of potential factors. 74% of leukemia in this group occurred within 2 to 9 years after diagnosis of ovarian cancer, of which acute or non-lymphocytic leukemia accounted for 89% of the total number of leukemia. Different treatment methods have different relative risks. If the relative risk of simple surgical treatment as 1, the risk of chemotherapy alone is 12, higher than the radiotherapy and chemotherapy 10, but the difference between the two is not obvious. The relative risk of radiotherapy alone was 1.6, with only a slight increase.