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目的探讨关节运动疗法联合药物治疗对老年帕金森病(PD)患者抑郁和认知障碍的影响。方法 2012年1月至2014年12月共收集PD合并抑郁患者80例,随机分为对照组和研究组,每组各40例,对照组给予药物疗法(多巴丝肼片和艾司西酞普兰),研究组在对照组基础上联合关节运动疗法,采用Beck抑郁问卷评价PD患者抑郁状态,简易智能精神状态检查量表(MMSE)评价认知功能,39项帕金森病调查表(PDQ-39)评价生活质量。结果治疗后,研究组患者Beck抑郁问卷评分明显低于对照组,MMSE评分明显高于对照组,PDQ-39评分明显低于对照组,差异均具有统计学意义(P<0.05)。结论关节运动疗法联合药物疗法可最大限度地发挥药物功效,明显缓解老年PD患者抑郁和认知障碍,改善患者生活质量。
Objective To investigate the effects of joint exercise therapy and drug therapy on depression and cognitive impairment in elderly patients with Parkinson’s disease (PD). Methods From January 2012 to December 2014, 80 patients with PD complicated with depression were enrolled and randomly divided into control group and study group, 40 cases in each group. The control group was given drug therapy (dopasuanidine tablets and escitalopram Pulan), the research group based on the control group combined with joint exercise therapy, the Beck depression questionnaire evaluation of depression in patients with PD, simple mental state examination (MMSE) evaluation of cognitive function, 39 Parkinson’s Disease Questionnaire (PDQ- 39) evaluate the quality of life. Results After treatment, the score of Beck Depression Questionnaire in study group was significantly lower than that in control group, MMSE score was significantly higher than that in control group, and PDQ-39 score was significantly lower than that in control group (P <0.05). Conclusion The combination of arthroplasty and drug therapy can maximize drug efficacy, relieve depression and cognitive impairment in elderly patients with PD, and improve the quality of life of patients.