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[目的]观察氟伐他汀联合缬沙坦对慢性充血性心力衰竭患者血清BNP水平和心功能的影响。[方法]100例慢性充血性心力衰竭患者随机分为治疗组和对照组。对照组给予缬沙坦及常规治疗,治疗组在此基础上加用氟伐他汀,疗程均为1年。比较两组治疗前后血清BNP水平的变化和心功能疗效及心脏彩超指标。[结果]治疗组1年后血清BNP水平较对照组显著下降(P﹤0.05);心功能改善总有效率显著优于对照组(P﹤0.05);左心室射血分数(LVEF)、左室舒张末内径(LVEDd)均较对照组有明显改善(P﹤0.05)。[结论]氟伐他汀联合缬沙坦治疗慢性充血性心力衰竭能显著降低患者血清BNP水平,明显改善心功能,疗效优于单加缬沙坦。
[Objective] To observe the effect of fluvastatin combined with valsartan on serum BNP level and cardiac function in patients with chronic congestive heart failure. [Method] 100 patients with chronic congestive heart failure were randomly divided into treatment group and control group. Control group was given valsartan and conventional treatment, the treatment group on the basis of the use of fluvastatin, treatment were 1 year. The changes of serum BNP levels, cardiac function and the indexes of cardiac ultrasound before and after treatment were compared between the two groups. [Results] The serum BNP level of the treatment group decreased significantly (P <0.05) one year later than that of the control group, and the total effective rate of improvement of cardiac function was significantly better than that of the control group (P <0.05). Left ventricular ejection fraction Diastolic diameter (LVEDd) were significantly improved compared with the control group (P <0.05). [Conclusion] Fluvastatin combined with valsartan in the treatment of chronic congestive heart failure can significantly reduce the level of serum BNP in patients with significant improvement of cardiac function, with better curative effect than valsartan alone.