目的 :了解血管紧张素转换酶 (ACE)基因多态性与新疆地区原发性高血压的易感相关性。方法:应用聚合酶链反应 (PCR)对 78例新疆地区原发性高血压患者与 72例正常血压对照者 ACE基因第 16内含子插入 /缺失多态性进行鉴定。结果:在新疆地区原发性高血压患者中 ,ACE基因缺失纯合基因型 (DD)和缺失 (D)等位基因频率均明显高于正常血压者 (P <0 .0 5及 P <0 .0 1)。结论:ACE基因缺失纯合型可能是新疆地区原发性高血压遗传易感因素之一 Objective: To understand the relationship between angiotensin converting enzyme (ACE) gene polymorphism and susceptibility to essential hypertension in Xinjiang. Methods: Polymerase chain reaction (PCR) was used to identify the 16th intron insertion / deletion polymorphism of ACE gene in 78 patients with essential hypertension and 72 normal controls in Xinjiang. Results: The frequencies of the homozygous (DD) and deletion (D) alleles of ACE gene deletion were significantly higher in patients with essential hypertension in Xinjiang than those with normal blood pressure (P <0.05 and P <0.05) .0 1). Conclusion: The lack of homozygosity of ACE gene may be one of the predisposing factors of essential hypertension in Xinjiang