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目的观察布地奈德联合肾上腺素雾化吸入治疗小儿急性感染性喉炎的临床疗效。方法选择武汉科技大学附属天佑医院2010年5月—2013年10月住院治疗的78例急性感染性喉炎患儿,随机分为对照组38例和观察组40例。对照组在常规治疗基础上加用地塞米松治疗,观察组在常规治疗基础上加用布地奈德联合肾上腺素雾化吸入治疗。比较两组患儿临床疗效、临床症状(吸气性喉鸣、犬吠样咳嗽、声嘶)消失时间及住院时间。结果观察组总有效率高于对照组,吸气性喉鸣、犬吠样咳嗽、声嘶消失时间及住院时间短于对照组(P<0.05);两组患儿治疗期间未发生严重不良反应。结论布地奈德联合肾上腺素雾化吸入治疗急性感染性喉炎的临床疗效显著,可明显缩短临床症状消失时间和住院时间。
Objective To observe the clinical efficacy of budesonide combined with epinephrine nebulization in the treatment of acute infectious laryngitis in children. Methods A total of 78 children with acute infectious laryngitis hospitalized from May 2010 to October 2013 in Tianyou Hospital of Wuhan University of Science and Technology were randomly divided into control group (n = 38) and observation group (n = 40). The control group was treated with dexamethasone on the basis of conventional treatment. The observation group was treated with budesonide and epinephrine nebulized inhalation on the basis of routine treatment. The clinical efficacy, clinical symptoms (inspiratory larynx, bark-like cough, hoarseness) disappeared and hospital stay were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group. Inhale throat, bark-like cough, disappearance of hoarseness and hospital stay were shorter than those in the control group (P <0.05). No serious adverse reactions occurred in the two groups during treatment. Conclusion Budesonide combined with epinephrine nebulization in the treatment of acute infectious laryngitis significant clinical effect, can significantly shorten the disappearance of clinical symptoms and hospitalization time.