betatrophin为一种新发现的分泌蛋白,主要在肝脏和脂肪组织中表达。目前大部分研究提示betatrophin可显著、特异性地促进β细胞增殖,从而改善机体对糖的耐受。但有研究不支持以上观点,betatrophin对β细胞的确切作用、作用机制、影响因素等有待进一步研究。 Betatrophin is a newly discovered secreted protein that is mainly expressed in the liver and adipose tissue. Most studies suggest that betatrophin can significantly and specifically promote β-cell proliferation, thus improving the body’s tolerance to sugar. However, some studies do not support the above point of view, betatrophin on the exact role of β-cell, the mechanism of action, factors need to be further studied.