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香豆素是一类重要的天然产物。以4-羟基香豆素为原料,在三乙胺和四氯化碳存在的条件下,分别与不同的亚磷酸酯在甲醇中反应,得到了7种标题化合物,其结构均经过IR、MS和1HNMR的表征。对反应溶剂、温度、物料比和时间等影响因素进行了优化,得到一种操作简单、条件温和、产率较高的合成路线。
Coumarins are a class of important natural products. Using 4-hydroxycoumarin as starting material, different title phosphites were reacted in methanol in the presence of triethylamine and carbon tetrachloride to give the title compounds, all of which were characterized by IR, MS And 1HNMR characterization. The influencing factors such as reaction solvent, temperature, material ratio and time were optimized, and a synthetic route with simple operation, mild conditions and high yield was obtained.