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糖尿病与糖化血红蛋白测定山西省人民医院(030012)张美兰,荣秀芹我们采用亲和层析法测定探讨糖尿病人糖化血红蛋白、血糖及几种合并症之间的关系,为临床糖尿病研究提供一定的数据。对象和方法取我院门诊、住院确诊为糖尿病的病人46人,年龄40岁~70岁,糖尿病病程3个月~12年,其中8例糖尿病合并末梢神经炎,7例合并肾脏损害,1例合并白内障,4例低T3综合征,26例无合并症,空腹餐后2小时血糖控制较好,正常体检20例,为对照,男15例,女20例;年龄40岁~60岁。结果糖尿病组HbAlc为10.4±0.9,正常组为5.89±0.8;糖尿病合并肾损与血糖HbAlc的关系见附表。讨论糖化血红蛋白采用亲和层析法,具有操作灵敏,反应准确的功能,而不受空腹,餐后,药物对血糖的影响。国外许多资料提倡只要查一次糖化血红蛋白,加上餐后2小时血糖、24小时尿糖,就可确诊糖尿病,免做正规耐量试验。我们采用空腹血糖证实,空腹血糖大于7.8mmol/L的病人,糖化血红蛋白明显增高,慢性合并症重的病人糖化血红蛋白也高,而且较持久,糖化血红蛋白高达20%以上者,提示着糖尿病合并症的晚期。糖尿病与糖化血红蛋白测定@张美兰,荣秀芹$山西省人民医院
Diabetes mellitus and glycosylated hemoglobin determination Shanxi Provincial People’s Hospital (030012) Zhang Meilan, Rong Xiuqin We used affinity chromatography determination of glycated hemoglobin in patients with diabetes, blood glucose and several complications between the relationship for the clinical diabetes to provide some data . Subjects and methods Take our hospital outpatient, hospitalized diagnosed with diabetes, 46 patients, aged 40 to 70 years of age, duration of diabetes for 3 months to 12 years, of which 8 cases of diabetic peripheral neuritis, 7 cases of renal damage, 1 case of merger Cataracts, 4 cases of low T3 syndrome, 26 cases without complications, fasting blood glucose control 2 hours better, 20 cases of normal physical examination as control, 15 males and 20 females; aged 40 to 60 years old. Results HbAlc was 10.4 ± 0.9 in diabetic group and 5.89 ± 0.8 in normal group. The relationship between diabetic nephropathy and HbAlc in blood glucose is shown in the attached table. Discussion HbA1c using affinity chromatography, with sensitive, accurate response to the function, without being fasting, postprandial, the impact of drugs on blood glucose. Many foreign data advocate just check glycosylated hemoglobin, plus 2 hours postprandial blood glucose, 24-hour urine sugar, you can diagnose diabetes, so do the formal endurance test. We use fasting blood glucose confirmed that patients with fasting blood glucose greater than 7.8mmol / L, glycosylated hemoglobin was significantly higher in patients with chronic complications of glycosylated hemoglobin is also high, and more durable, glycosylated hemoglobin up to 20% or more, suggesting that diabetic complications Late. Diabetes mellitus and glycosylated hemoglobin determination @ Meilan, Rongxiu Qin $ Shanxi Provincial People’s Hospital