论文部分内容阅读
目的:研究安雪颗粒治疗眼底出血的药效学。方法:采用小鼠断尾法及小鼠全身肝素化观察安雪颗粒止血、凝血作用,并观察安雪颗粒对醋酸所致小鼠腹腔毛细血管通透性的影响和对大鼠血液流变性的影响。结果:实验结果显示安雪颗粒能缩短小鼠断尾止血及凝血时间,能缩短全身肝素化小鼠凝血时间,抑制醋酸所致小鼠腹腔毛细血管通透性的增高,能降低血液黏度,改变血液流变性。结论:安雪颗粒具有显著的止血和活血化瘀作用。
OBJECTIVE: To study the pharmacodynamics of An Xue granules in the treatment of retinal hemorrhage. Methods: The hemostatic and coagulation effects of Xuexue Granules were observed by the tail-off method and systemic heparinization in mice. The effects of Xuexue Granule on the peritoneal capillary permeability of mice induced by acetic acid and the effects on blood rheology influences. Results: The experimental results showed that An Xue Granule can shorten the tail stop bleeding and clotting time in mice, can shorten the coagulation time of heparinized mice and inhibit the increase of peritoneal capillary permeability induced by acetic acid in mice, which can reduce the blood viscosity and change Hemorheology. Conclusion: Xuexue Granule has significant hemostatic and blood circulation.