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目的了解712例疑似药物滥用者尿氯胺酮、冰毒、吗啡筛查情况,并分析尿检阳性者人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)、梅毒(TP)、乙型肝炎病毒(HBV)感染情况及丙氨酸氨基转移酶(ALT)水平。方法 2010年1月至2015年7月该院712例住院、门诊怀疑药物滥用者均进行尿氯胺酮、冰毒、吗啡筛查,并对1种毒品以上筛查阳性者进行HIV、HCV、TP、HBV及ALT检测,同时给予问卷调查。结果 712例怀疑药物滥用者中,尿检阳性256例。男性与女性药物滥用筛查阳性者HIV、HCV、TP、HBV感染阳性率比较,差异均无统计学意义(P>0.05)。药物滥用者中,HCV、HBV阳性合并ALT升高者比例与HCV、HBV阴性者ALT升高者比例比较,差异均有统计学意义(P<0.05)。结论药物滥用在该区形势严峻,应采取综合干预措施控制HIV、HBV、HCV在药物滥用人群中蔓延,对药物滥用者建议筛查ALT,并对ALT水平升高者应积极治疗。
Objective To investigate the screening status of urine ketamine, methamphetamine and morphine in 712 suspected drug abusers and to analyze the positive rates of human immunodeficiency virus (HIV), hepatitis C virus (HCV), syphilis (TP), hepatitis B virus (HBV) ) Infection and alanine aminotransferase (ALT) levels. Methods From January 2010 to July 2015, 712 hospitalized and outpatient suspected drug abusers were enrolled in the study of urinary ketamine, methamphetamine and morphine screening, and HIV, HCV, TP, HBV And ALT test, at the same time give a questionnaire. Results Among 712 suspected drug abusers, 256 urine tests were positive. The positive rates of HIV, HCV, TP and HBV infection were not significantly different between male and female drug abuse screening positive persons (P> 0.05). Among drug abusers, the proportion of patients with positive HCV and HBV infection with elevated ALT was significantly higher than that of HCV and HBV-negative patients with ALT (P <0.05). Conclusion Drug abuse is a serious problem in the area. Comprehensive interventions should be taken to control the spread of HIV, HBV and HCV among drug abusers. For substance abusers, ALT should be screened, and ALT levels should be actively treated.