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不同个体对牙周感染的反应性不同,这是受遗传因素的影响,至今尚未在成人牙周炎患者中发现特异的基因标志。IL-1和TNFα在炎症反应中起重要的调节作用,并影响细胞基质和骨的代谢。近年国外学者研究编码这些细胞因子的基因及其对牙周炎的影响。研究表明,TNFα基因位于6号染色体上HLA复合体的第Ⅲ区,而IL-1基因簇是位于2号染色体的短臂13带上,并分为3类,分别是编码IL-1_A和IL-1_B(即IL-1α和IL-1β的前体)的基因,以及产生IL-1受体拮抗蛋白(与IL-1受体结合而不引发细胞内反应的蛋白质)IL-1RN的基因,且IL-1基因簇具有多态性,某些基因
Different individuals have different responses to periodontal infections due to genetic factors. To date, no specific genetic markers have been found in adult patients with periodontitis. IL-1 and TNFα play an important regulatory role in the inflammatory response and affect the cellular matrix and bone metabolism. In recent years, foreign scholars study the genes encoding these cytokines and their effects on periodontitis. Studies have shown that the TNFα gene is located in the region III of the HLA complex on chromosome 6 and the IL-1 gene cluster is located on the short arm 13 of chromosome 2 and is classified into three groups, encoding IL-1_A and IL -1_B, which is a precursor of IL-1α and IL-1β, and IL-1RN, which produces an IL-1 receptor antagonist protein that binds to the IL-1 receptor without inducing an intracellular response, And IL-1 gene cluster polymorphism, some genes