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目的探讨新辅助化疗对Ⅲ期乳腺癌术后局部复发的预防作用。方法活检组织病理确诊Ⅲ期乳腺癌患者(无远处转移)104例,根据是否行新辅助化疗分为2组。新辅助化疗组58例术前应用CAF(环磷酰胺+阿霉素+氟尿嘧啶)方案化疗2个或4个疗程,化疗结束7d后行乳腺癌根治术。对照组46例直接行乳腺癌根治术。2组术后14d均行辅助化疗,并根据淋巴结转移情况行序贯放疗。术后随访2a,比较2组局部复发情况。结果新辅助化疗组复发率5.1%(3/58),对照组复发率17.3%(8/46),2组比较差异有统计学意义(P<0.05)。结论新辅助化疗可降低Ⅲ期乳腺癌术后局部复发率。
Objective To investigate the preventive effect of neoadjuvant chemotherapy on postoperative local recurrence of stage Ⅲ breast cancer. Methods Totally 104 breast cancer patients with stage Ⅲ biopsy (without distant metastasis) were divided into two groups according to whether they received neoadjuvant chemotherapy. In the neoadjuvant chemotherapy group, 58 cases were treated with CAF (cyclophosphamide plus doxorubicin + fluorouracil) regimen for 2 or 4 courses of chemotherapy before operation, and radical mastectomy was performed 7 days after the end of chemotherapy. The control group of 46 patients underwent radical mastectomy. Adjuvant chemotherapy was given on the 14th postoperative day in both groups, and sequential radiotherapy was performed according to the lymph node metastasis. The patients were followed up for 2 years and the local recurrences were compared between the two groups. Results The recurrence rate was 5.1% (3/58) in the neoadjuvant chemotherapy group and 17.3% (8/46) in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion Neoadjuvant chemotherapy can reduce the postoperative local recurrence rate of stage Ⅲ breast cancer.