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目的观察达英-35联合二甲双胍及适当有氧运动治疗多囊卵巢综合征(polycystic ovarian syndrome,PCOS)的临床疗效。方法随机选取2012年1月—2014年2月深圳市宝安区某医院收治的PCOS患者200例作为研究对象,随机分为治疗组和对照组各100例。对照组月经第5天给予达英-35联合二甲双胍治疗,治疗组在对照组治疗的基础上再适当有氧运动治疗,并观察两组患者性激素指标、血糖指标、BMI和血脂指标水平及疗效。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,治疗组的T、E2、LH、LEP、FSH、LH/FSH比值、FGlu、FIns、HOMA-IR、TC、TG、LDL-C以及HDL-C、BMI分别为:(2.5±0.5)mmol/L、(127.2±20.1)pmol/L、(6.4±2.3)IU/L、(11.2±3.8)ng/ml、(9.4±1.7)IU/L、(0.7±0.8)、(5.2±1.0)mmol/L、(13.2±6.8)IU/L、(3.0±1.6)、(3.8±0.5)、(1.1±0.5)、(2.2±0.5)、(1.9±0.5)、(22.6±4.1)mmol/L;对照组分别为:(3.1±0.6)mmol/L、(147.2±22.6)pmol/L、(9.4±2.3)IU/L、(14.5±4.6)ng/ml、(8.2±1.9)IU/L、(1.1±0.9)、(6.0±1.3)mmol/L、(18.2±10.3)IU/L、(4.9±2.6)、(5.4±0.6)、(2.0±0.6)、(3.2±0.6)、(1.1±0.4)、(25.4±4.3)mmol/L,治疗组较对照组均有明显改善,对比差异均有统计学意义(均P<0.05)。治疗后,治疗组患者排卵率和妊娠成功率分别为95.00%、80.00%,对照组排卵率和妊娠成功率分别为65.00%、37.00%,治疗组患者排卵率和妊娠成功率较对照组均有明显改善,对比差异均有统计学意义(均P<0.05)。治疗组治疗总有效率为95.00%,明显优于对照组的总有效率(65.00%),对比差异有统计学意义(P<0.05)。结论达英-35联合二甲双胍及适当有氧运动治疗PCOS的临床疗效较达英-35联合二甲双胍的效果好,能够降血脂血糖、更好地调节机体内分泌、提高妊娠成功率,值得临床应用及推广。
Objective To observe the curative effect of da-Ying-35 combined with metformin and proper aerobic exercise on polycystic ovarian syndrome (PCOS). Methods A total of 200 PCOS patients were randomly selected from a hospital in Bao’an District of Shenzhen City from January 2012 to February 2014 as study subjects and randomly divided into treatment group and control group with 100 cases each. The control group received Dayang-35 combined with metformin on the 5th day of menstruation. The treatment group was treated with appropriate aerobic exercise on the basis of the control group. The levels of sex hormone, blood glucose, BMI, blood lipid and the therapeutic effect were observed. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the BMI of T, E2, LH, LEP, FSH, LH / FSH, FGlu, FIns, HOMA-IR, TC, TG, LDL-C and HDL- ) (mmol / L), (127.2 ± 20.1) pmol / L, 6.4 ± 2.3 IU / L, 11.2 ± 3.8 ng / ml, 9.4 ± 1.7 IU / L, 0.7 ± 0.8, 5.2 ± 1.01 mmol / L, 13.2 ± 6.8 IU / L, 3.0 ± 1.6, 3.8 ± 0.5, 1.1 ± 0.5, 2.2 ± 0.5, (22.6 ± 4.1) mmol / L, (14.1 ± 0.6) mmol / L, (147.2 ± 22.6) pmol / L and (9.4 ± 2.3) IU / (1.1 ± 0.9), (6.0 ± 1.3) mmol / L, (18.2 ± 10.3) IU / L, 4.9 ± 2.6, 5.4 ± 0.6, 2.0 ± 0.6, 3.2 ± 0.6 ), (1.1 ± 0.4) and (25.4 ± 4.3) mmol / L respectively. The treatment group was significantly improved compared with the control group, the difference was statistically significant (all P <0.05). After treatment, the treatment group patients ovulation rate and pregnancy success rate were 95.00%, 80.00%, the control group ovulation rate and pregnancy success rates were 65.00%, 37.00%, the treatment group patients ovulation rate and pregnancy success rate than the control group Significant improvement, the difference was statistically significant (P <0.05). The total effective rate of the treatment group was 95.00%, which was significantly better than that of the control group (65.00%), the difference was statistically significant (P <0.05). Conclusion The combination of metformin and metformin and appropriate aerobic exercise in the treatment of PCOS has better curative effect than the combination of metformin and metformin, which can lower blood glucose, regulate endocrine and improve the success rate of pregnancy, which is worthy of clinical application and promotion .