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CD8+CD28-抑制性T细胞是一种重要的CD8+Treg,并且是典型的FoxP3-Treg。它不仅在自然老化过程中累积增加,而且在多种疾病的发生发展过程中显著增多,并通过多种机制对机体的免疫应答产生负向调节。本文就CD8+CD28-T细胞作为调节性T细胞的分子特征及其在不同疾病中的变化规律等研究进展作一综述。
CD8 + CD28-suppressor T cells are an important CD8 + Treg and are typical FoxP3-Tregs. It accumulates not only in the process of natural aging, but also in the process of occurrence and development of many diseases. It also regulates the immune response of the body negatively through various mechanisms. This review summarizes the molecular characteristics of CD8 + CD28-T cells as regulatory T cells and their changes in different diseases.