目的检测妊娠期糖尿病肾损伤患者血清胱抑素C(Cys-C)和β-2微量蛋白(β2-MG)的表达水平及临床意义。方法选择2014年1月—2015年6月郑州市第二人民医院收治的50例妊娠期糖尿病肾损伤患者作为病例组,其中中孕期25人,晚孕期25人。另选择25例健康中孕期和25例晚孕期妊娠者作为对照组。观察并分析病例组和对照组血清Cys-C和β2-MG水平。结果妊娠期糖尿病中孕期组和晚孕期组血清Cys-C和β2-MG水平均高于对照组,P<0.05,具有统计学意义。结论检测Cys-C和β2-MG对妊娠期糖尿病肾损伤的早期诊断有一定的临床指导意义。 Objective To detect the expression of cystatin C (Cys-C) and β-2 microglobulin (β2-MG) in patients with gestational diabetic nephropathy and its clinical significance. Methods From January 2014 to June 2015, 50 cases of gestational diabetic nephropathy admitted to the Second People’s Hospital of Zhengzhou City were selected as the case group, including 25 in the second trimester and 25 in the second trimester. Another 25 cases of healthy pregnancy and 25 cases of late pregnancy as control group. The levels of serum Cys-C and β2-MG were observed and analyzed in case group and control group. Results The levels of serum Cys-C and β2-MG in gestational diabetes mellitus during pregnancy and late pregnancy were significantly higher than those in control group (P <0.05). Conclusion The detection of Cys-C and β2-MG in early diagnosis of gestational diabetic kidney injury has some clinical significance.