妊娠高血压综合征(PIH,妊高征)是妊娠期特有的并发症,严重危害母婴健康。其基本病理生理改变是全身小动脉痉挛,临床表现为高血压、水肿、蛋白尿。妊高征病因及发病机制尚未阐明。经过近百年的努力,妊高征病因学研究从最初的临床资料总结→动物模型的建立→组织细胞学观察,直至分子生物学水平研究,但目前尚无一种学说能完整,系 Pregnancy-induced hypertension (PIH, PIH) is a unique complication of pregnancy, seriously endangering the health of mothers and infants. The basic pathophysiological changes of systemic arteriole spasm, clinical manifestations of hypertension, edema, proteinuria. The causes and pathogenesis of PIH have not been elucidated yet. After nearly a hundred years of efforts, the study of etiology of PIH from the initial clinical data summary → animal model establishment → histocytology observation, until the molecular biology level, but there is no one theory can be complete, Department