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目的分析神经梅毒(nurosyphilis,NS)的临床特点并提高对该病的临床诊断水平。方法对11例NS患者的临床资料进行回顾性分析。结果 11例NS均被确诊,无症状NS7例,脑膜血管梅毒3例,脑实质梅毒1例。其中脑脊液梅毒螺旋体明胶颗粒试验(treponema pallidum particle assay,TPPA)阳性者11例(100%),蛋白增高者9例(82%),细胞数增高者7例(64%)。血清TPPA和快速血浆反应素环状卡片试验(rapid plasma reagin,RPR)都是阳性。结论 NS的诊断目前尚无金标准,应结合临床表现和实验室检查等综合分析。尽早发现无症状型NS,减少漏诊、误诊。
Objective To analyze the clinical features of nurosyphilis (NS) and to improve the clinical diagnosis of the disease. Methods The clinical data of 11 patients with NS were retrospectively analyzed. Results All the 11 cases were diagnosed as NS, asymptomatic NS7 cases, meningeal vascular syphilis in 3 cases and brain parenchymal syphilis in 1 case. 11 (100%) were positive for cerebrospinal fluid treponema pallidum particle assay (TPPA), 9 were (82%) higher in protein and 7 (64%) were higher in cell count. Serum TPPA and rapid plasma reagin (RPR) were positive. Conclusion The diagnosis of NS is currently no gold standard, should be combined with clinical manifestations and laboratory tests and other comprehensive analysis. Asymptomatic NS as soon as possible, to reduce missed diagnosis, misdiagnosis.