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目的分析心肌梗死介入治疗中血栓抽吸联合盐酸替罗非班治疗的效果。方法 2013年12月至2015年4月笔者收集急诊经皮冠状动脉介入(PCI)治疗的急性ST段抬高性心肌梗死(STEMI)64例,冠状动脉造影提示高度血栓负荷。根据治疗方法随机分为观察组(血栓抽吸联合盐酸替罗非班)和对照组(仅行PCI术)。结果 PCI术后,观察组MPG 3级以及TIMI血流3级发生率均高于对照组;随访1年,观察组主要心血管不良时间(MACE)、靶血管血运重建(TVR)及靶病变再次血运重建(TLR)发生率均低于对照组(P均<0.05)。结论血栓抽吸联合盐酸替罗非班能显著改善高度血栓负荷的急性ST段抬高性心肌梗死患者TMPG分级、TIMI血流,改善患者1年生存质量。
Objective To analyze the effect of thrombus aspiration combined with tirofiban hydrochloride in interventional treatment of myocardial infarction. Methods From December 2013 to April 2015, we collected 64 cases of acute ST-segment elevation myocardial infarction (STEMI) treated by emergency percutaneous coronary intervention (PCI). Coronary angiography showed high thrombus burden. According to the treatment, they were randomly divided into observation group (thrombectomy combined with tirofiban hydrochloride) and control group (PCI only). Results After PCI, the incidence of MPG grade 3 and TIMI grade 3 in observation group were higher than those in control group. After one year of follow-up, MACE, target vessel revascularization (TVR) and target lesion The incidence of revascularization (TLR) was lower than that of the control group (all P <0.05). Conclusion Thrombus aspiration combined with tirofiban hydrochloride can significantly improve TMPG grade and TIMI blood flow in patients with acute ST-elevation myocardial infarction with high thrombus burden and improve 1-year quality of life.