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作者收集了194例肝细胞癌(HCC)组及456例住院对照组的吸烟、饮酒史,并对该结果连同所有病例的HBsAg、抗-HBs和抗-HBc的血清学检测结果及HCC有无肝硬化作了分析。HBsAg阳性者中,肝细胞癌的相对危险度(RR)为13.7(8.0～23.5),而抗-HBs阳性者中,危险度小,但无统计学差异。有肝硬化而HBsAg阳性者的相对危险度明显较高(与无肝硬化而HBsAg阳性者相比为30.7:7.1)。提示HBV影响肝细胞癌的发生至少通过两个不同的潜在机理(DNA整合和肝细胞的再生)。适量的乙醇消耗不影响肝细胞癌的相对危险度,但吸烟与HBsAg阴性的肝细胞癌之间有统计学意义并有剂量依赖关系。在欧洲
The authors collected smoking and drinking history from 194 cases of hepatocellular carcinoma (HCC) and 456 inpatient controls, and together with the results, together with the serological test results of HBsAg, anti-HBs and anti-HBc in all cases, and whether HCC Liver cirrhosis was analyzed. Among the HBsAg-positive patients, the relative risk (RR) of hepatocellular carcinoma was 13.7 (8.0 to 23.5), while those with anti-HBs were less risky, but there was no statistical difference. The relative risk of cirrhosis and HBsAg positive patients was significantly higher (30.7 vs. 7.1 compared with HBsAg positive patients without cirrhosis). It suggests that HBV affects the occurrence of hepatocellular carcinoma through at least two different underlying mechanisms (DNA integration and regeneration of hepatocytes). Amount of ethanol consumption did not affect the relative risk of hepatocellular carcinoma, but there was a statistically significant and dose-dependent relationship between smoking and HBsAg-negative hepatocellular carcinoma. in Europe