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药物重定位(又称老药新用)是指已上市药物发现新适应症或新用途,其不仅在西药研发中受到越来越多的关注,在中药新药研究领域也逐渐成为热门。目前,药物重定位研究已进入基于计算机技术的新阶段,其研究方法、技术得到不断地完善。网络药理学方法在药物重定位研究方面发挥着越来越重要的作用,目前其应用于中药药物重定位研究中的策略主要包括基于小分子(或配体)、基于药物靶点和基于网络理论三方面。本文对中药药物重定位的概念、研究现状及网络药理学的应用现状及策略进行介绍,以期为中药药物重定位研究提供参考。
Drug relocation (also known as the old drug used) refers to the new drug discovery or new drug has been marketed, which not only in the development of Western medicine by more and more attention in the field of new drug research in traditional Chinese medicine has become increasingly popular. At present, researches on drug relocation have entered a new stage based on computer technology, and their research methods and techniques have been continuously improved. Network pharmacological methods play more and more important roles in the study of drug relocation. At present, the strategies used in the study of drug repositioning in traditional Chinese medicine mainly include small molecule (or ligand), drug target-based and network-based theory three sides. In this paper, the concept of drug relocation of Chinese medicine, research status and application of network pharmacology status quo and strategies are introduced in order to provide a reference for traditional Chinese medicine drug relocation research.