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目的 探索β１ 整合素表达与髓母细胞瘤各病理类型和临床预后的关系。方法 单克隆抗体对８０ 例手术切除的髓母细胞瘤的福尔马林固定石蜡切片行免疫组织化学染色， 结合临床随访，使用 Ｃｏｘ 回归和 Ｐｅａｒｓｏｎ 相关统计分析。结果 多数髓母细胞瘤表达β１ 整合素。结论 典型性、纤维性、多形性三种病理类型的髓母细胞瘤β１ 整合素表达无明显差别； β１ 整合素表达与髓母细胞瘤临床预后存在高度负相关关系， 即β１ 整合素表达愈高， 其临床预后愈差。
Objective To explore the relationship between the expression of β1 integrin and the pathological types and clinical prognosis of medulloblastoma. Methods Monoclonal antibodies were immunohistochemically stained for formalin-fixed paraffin sections of 80 surgically resected medulloblastoma. Cox regression and Pearson correlation analysis were used in combination with clinical follow-up. Results Most medulloblastomas expressed β1 integrin. Conclusion There is no significant difference in the expression of β1 integrin in the three pathological types of medulloblastoma, which are typical, fibrous and pleomorphic. The expression of β1 integrin has a highly negative correlation with clinical prognosis of medulloblastoma, that is, the expression of β1 integrin High, the worse the clinical prognosis.