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目的:临床探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)导致阴茎勃起功能障碍(ED)与外周血一氧化氮(NO)和一氧化氮合酶(NOS)水平的相关性。方法:经多导睡眠监测仪(PSG)及阴茎夜间勃起功能测定(NPT),诊断OSAHS合并ED患者60名作为ED组,同时随机选择30名健康志愿者设立为健康组,分析ED组和健康组血清NO和NOS水平,及轻、中、重ED组血清NO、NOS水平、阴茎血容积变化率及IIEF-5总分差异,并将轻、中、重ED组阴茎血容积变化率及IIEF-5总分分别与各自血清NO和NOS水平进行相关性分析。结果:ED组的外周血NO和NOS水平均低于无ED组和健康组,差异具有统计学意义(P<0.05)。阴茎血容积变化率与NO(r=0.356,P<0.05)、NOS(r=0.398,P<0.05)均为正相关;IIEF-5总分与NO(r=0.402,P<0.05)、NOS(r=0.423,P<0.05)均为正相关。结论:OSAHS导致的ED患者与患者外周血NO和NOS水平变化情况的具有相关性,且呈正相关,说明外周血NO和NOS水平的降低是OSAHS导致ED的内在病理基础。
Objective: To investigate the relationship between erectile dysfunction (ED) and levels of nitric oxide (NO) and nitric oxide synthase (NOS) in peripheral blood of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: Sixty children with OSAHS complicated with ED were enrolled as ED group by polysomnography (PSG) and penile nocturnal erectile function test (NPT). At the same time, 30 healthy volunteers were randomly selected as healthy group to analyze ED group and health Serum NO and NOS levels, serum NO, NOS levels, penile blood volume change rate and IIEF-5 total score in light, medium and heavy ED groups, and the changes of penile blood volume change rate and IIEF -5 total score were correlated with their respective serum NO and NOS levels. Results: The levels of NO and NOS in peripheral blood in ED group were lower than those in non-ED group and healthy group (P <0.05). The change rate of penile blood volume was positively correlated with NO (r = 0.356, P <0.05) and NOS (r = 0.398, P <0.05) (r = 0.423, P <0.05). CONCLUSIONS: There is a positive correlation between OSAHS-induced ED patients and the changes of NO and NOS levels in peripheral blood. It is indicated that the decrease of NO and NOS levels in peripheral blood is the intrinsic pathological basis of OSAHS-induced ED.