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目的探讨肺表面活性蛋白(PS)作为矽肺早期生物标志物的可能性,为矽肺的早期诊断和临床治疗提供理论依据。方法 87名矽尘作业工人,按照接尘工龄分为大于10年组和小于以及等于10年组。应用酶联免疫分析法(ELISA)检测矽尘作业工人血清中SP-A、SP-B、SP-C、SP-D的蛋白含量。用斯皮尔曼分析方法确定PS和接尘工龄的相关性。结果矽尘作业工人血清中SP-A、SP-B、SP-C、SP-D含量随着接尘工龄的增加而增加。其中SP-A、SP-C和SP-D含量均与接尘工龄呈正相关。结论矽尘作业工人血清中SP含量发生改变,其中SP-C的水平可作为矽肺的早期效应标志物。
Objective To investigate the possibility of pulmonary surfactant protein (PS) as an early biomarker of silicosis and to provide a theoretical basis for the early diagnosis and clinical treatment of silicosis. Methods A total of 87 workers working on silica dust were divided into groups of more than 10 years and less than and equal to 10 years according to the age of dust collection. The protein contents of SP-A, SP-B, SP-C and SP-D in sera of workers exposed to silica dust were detected by enzyme linked immunosorbent assay (ELISA). Spearman analysis method was used to determine the correlation between PS and the service life of dust. Results The levels of SP-A, SP-B, SP-C and SP-D in serum of workers exposed to silica dust increased with the increase of the service life of dust. The contents of SP-A, SP-C and SP-D were positively correlated with the age of dust pick-up. Conclusion The content of SP in serum of workers exposed to silica dust changes. The level of SP-C can be used as an early effect marker of silicosis.