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目的:回顾性分析Ⅰ和Ⅱ期中心型非小细胞肺癌介入治疗合并放射治疗的疗效。方法23例因医学原因不能手术治疗或拒绝手术治疗的Ⅰ和Ⅱ期中心型非小细胞肺癌,行支气管动脉单纯性化疗灌注2次后,行肺部肿瘤受累野的局部放疗,全部病例行常规分割放射治疗技术,中位照射剂量60Gy,此组为治疗组。并与随机抽取的同期Ⅰ和Ⅱ期中心型非小细胞肺癌行单纯放射治疗的23例患者对照,此组为对照组。结果治疗后3月,原发灶完全缓解率:治疗组和观察组分别为47.8%,21.7%,总有效率为95.7%%和86.9%,3、5年生存率治疗组和观察组分别为56.5%和30.4%;34.8%和13.0%;肺早晚期反应较轻,无3级放射性肺炎和放射性食管炎发生,两组放疗反应相似。结论介入治疗合并放射治疗的方法对不能手术的Ⅰ和Ⅱ期中心型非小细胞肺癌疗效好,较单纯放疗生存率较高,而且放射反应轻,是一种安全有效的局部治疗手段。
Objective: To retrospectively analyze the efficacy of interventional radiotherapy in patients with stage I and II non-small cell lung cancer. Methods Twenty-three patients with stage Ⅰ and Ⅱ non-small cell lung cancer who were unable to be surgically treated or refused surgery due to medical reasons were treated with simple chemotherapy with bronchial artery infusion for 2 times and received local radiotherapy in the lung tumor-affected field. All cases were routinely treated Split radiotherapy technology, the median dose of 60Gy, this group for the treatment group. The control group was compared with 23 patients with simple radiotherapy of randomly selected stage Ⅰ and Ⅱ central non-small cell lung cancer. Results After 3 months of treatment, the complete remission rate of the primary tumor was 47.8% and 21.7% respectively in the treatment group and the observation group, with a total effective rate of 95.7% and 86.9%. The 3 and 5-year survival rates of the treatment group and the observation group were 56.5% and 30.4%, 34.8% and 13.0%, respectively. The response of lung in early and late stage was mild, without grade 3 pneumonitis and radiation esophagitis. The radiotherapy response was similar in both groups. Conclusion Interventional radiotherapy combined with radiotherapy is a safe and effective local treatment for patients with stage Ⅰ and Ⅱ non-small-cell lung cancer who are inoperable. Compared with radiotherapy alone, radiotherapy is more effective than radiotherapy alone.